Structural biology of old world and new world alphaviruses.
نویسندگان
چکیده
A. Paredes1,∗, S. Weaver2, S. Watowich3,4, and W. Chiu1 1National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, U.S.A. 2Department of Pathology, University of Texas Medical Branch, Galveston, TX, U.S.A. 3Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX, U.S.A. 4Department of Sealy Center for Structural Biology, University of Texas Medical Branch, Galveston, TX, U.S.A.
منابع مشابه
Structure of the recombinant alphavirus Western equine encephalitis virus revealed by cryoelectron microscopy.
Western equine encephalitis virus (WEEV; Togaviridae, Alphavirus) is an enveloped RNA virus that is typically transmitted to vertebrate hosts by infected mosquitoes. WEEV is an important cause of viral encephalitis in humans and horses in the Americas, and infection results in a range of disease, from mild flu-like illnesses to encephalitis, coma, and death. In addition to spreading via mosquit...
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Alphaviruses are widely distributed throughout the world. During the last few thousand years, the New World viruses, including Venezuelan equine encephalitis virus (VEEV) and eastern equine encephalitis virus (EEEV), evolved separately from those of the Old World, i.e., Sindbis virus (SINV) and Semliki Forest virus (SFV). Nevertheless, the results of our study indicate that both groups have dev...
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Old World alphaviruses were identified in 52 of 623 horses with febrile or neurologic disease in South Africa. Five of 8 Sindbis virus infections were mild; 2 of 3 fatal cases involved co-infections. Of 44 Middelburg virus infections, 28 caused neurologic disease; 12 were fatal. Middelburg virus likely has zoonotic potential.
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The genus Alphavirus comprises a diverse group of viruses, including some that cause severe disease. Using full-length sequences of all known alphaviruses, we produced a robust and comprehensive phylogeny of the Alphavirus genus, presenting a more complete evolutionary history of these viruses compared to previous studies based on partial sequences. Our phylogeny suggests the origin of the alph...
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ورودعنوان ژورنال:
- Archives of virology. Supplementum
دوره 19 شماره
صفحات -
تاریخ انتشار 2005